Every cloud has a silver lining.
نویسندگان
چکیده
phamide, and Rituximab Versus FCR Alone in Subjects With Relapsed Chronic Lymphocytic Leukemia] study).8 If the results of this pivotal trial confirm the findings of Byrd et al,7 it will have an important influence on the treatment strategy of patients with CLL. In recent years, 4 drug combination therapies with FCR and alemtuzumab or FCR and mitoxantrone in refractory/relapsed CLL patients were also investigated9,10 (see figure). However, the results were less impressive than those reported in the present study of Byrd et al7 CFAR (FCR alemtuzumab) immunochemotherapy was evaluated in heavily pretreated patients with up to 14 previous therapies.9 Of the 74 patients, 18 (24%) achieved CR, 2 nodular partial response, and 28 partial response. The OR was 65%. In another randomized phase 2 study, Hillmen et al10 compared an FCM (fludarabine cyclophosphamide mitoxantrone) regimen with FCM plus rituximab in previously treated CLL. In this study, a 4-drug regimen induced a higher CR and CR(i) rate (43%) than FCM alone (13%) (see figure). However, the study design did not allow for a statistical comparison of the 2 combinations. In conclusion, despite the significant progress made in recent years, available therapies for refractory/relapsed CLL are only partially effective, and there is an obvious need to develop better strategies and new, more specific and active drugs. Conflict-of-interest disclosure: The author received research grants from Hoffman-LaRoche and Biogen Idec, and serves/has served as a consultant with Hoffman-LaRoche and Biogen Idec. ■
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ورودعنوان ژورنال:
- Blood
دوره 115 3 شماره
صفحات -
تاریخ انتشار 2006